Cutibacterium acnes as an Opportunistic Pathogen: An Update of Its Virulence-Associated Factors

C Mayslich, PA Grange, N Dupin - Microorganisms, 2021 - mdpi.com
Cutibacterium acnes is a member of the skin microbiota found predominantly in regions rich
in sebaceous glands. It is involved in maintaining healthy skin and has long been …

Acne, microbiome, and probiotics: The gut–skin axis

P Sánchez-Pellicer, L Navarro-Moratalla… - Microorganisms, 2022 - mdpi.com
The objective of this narrative review was to check the influence of the human microbiota in
the pathogenesis of acne and how the treatment with probiotics as adjuvant or alternative …

TREM2 macrophages induced by human lipids drive inflammation in acne lesions

TH Do, F Ma, PR Andrade, R Teles… - Science …, 2022 - science.org
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …

Crosstalk between ER stress, NLRP3 inflammasome, and inflammation

W Li, T Cao, C Luo, J Cai, X Zhou, X Xiao… - Applied microbiology and …, 2020 - Springer
Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

Acne vulgaris

SM Tuchayi, E Makrantonaki, R Ganceviciene… - Nature reviews Disease …, 2015 - nature.com
Acne vulgaris is a chronic inflammatory disease—rather than a natural part of the life cycle
as colloquially viewed—of the pilosebaceous unit (comprising the hair follicle, hair shaft and …

Inflammasomes

MR de Zoete, NW Palm, S Zhu… - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Inflammasomes are large cytosolic multiprotein complexes that assemble in response to
detection of infection-or stress-associated stimuli and lead to the activation of caspase-1 …

[HTML][HTML] Recent advances in understanding Propionibacterium acnes (Cutibacterium acnes) in acne

E Platsidaki, C Dessinioti - F1000Research, 2018 - ncbi.nlm.nih.gov
The skin commensal Propionibacterium acnes, recently renamed Cutibacterium acnes,
along with the other major pathophysiological factors of increased seborrhea …

Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

BC Melnik - Clinical, cosmetic and investigational dermatology, 2015 - Taylor & Francis
Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to
Western diet. Three major food classes that promote acne are: 1) hyperglycemic …

Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle

BC Melnik - Clinics in dermatology, 2018 - Elsevier
Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and
represents the most common skin disease affecting about 85% of adolescents in …

Cytosolic recognition of microbes and pathogens: inflammasomes in action

JA Hayward, A Mathur, C Ngo… - … and Molecular Biology …, 2018 - Am Soc Microbiol
Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …