Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Ameliorating T cell exhaustion and enhancing effector function are promising strategies for
the improvement of immunotherapies. Here, we show that the HPK1-NFκB-Blimp1 axis …

An analysis of published data appertaining to the cytokine storms of COVID-19, H1N1
influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) …

The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …

Nuclear factor-κB (NF-κB) controls genes involved in normal lymphocyte functions, but
constitutive NF-κB activation is often associated with B cell malignancy. Using high …

Antigen stimulation of T cell receptor (TCR) signaling to nuclear factor (NF)-κB is required for
T cell proliferation and differentiation of effector cells. The TCR-to-NF-κB pathway is …

T cell memory plays a critical role in our protection against pathogens and tumors. The
antigen and its interaction with the T cell receptor (TCR) is one of the initiating elements that …

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways
are involved in cell immune responses, apoptosis and infections. In multiple sclerosis (MS) …

Canonical nuclear factor κB (NF-κB) signaling mediated by homo-and heterodimers of the
NF-κB subunits p65 (RELA) and p50 (NFKB1) is associated with age-related pathologies …