The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

During the past four years, the research of new synthetic methodologies for the rapid
construction of enantiomerically pure substituted indole has had a fruitful and important …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

Chiral indole derivatives are an intriguing class of heterocyclic compounds; their structural
motifs are frequently found in natural products and synthetic compounds with significant …

3-Amino-2-oxindoles bearing tetra-substituted stereocenter are very important constituents
of many bioactive and pharmaceutical agents. In the last few years, asymmetric …

Phosphine‐catalyzed enantioselective annulation reactions involving ketimines are a
daunting synthetic challenge owing to the intrinsic low reactivity of ketimine substrates. A …

A highly enantioselective aza-Friedel–Crafts reaction of tryptanthrin-derived ketimines with
indoles/pyrrole using chiral phosphoric acid as a catalyst has been established. This …

A new strategy for the construction of optically active 5′-CF3 spiro [pyrrolidin-3, 2′-
oxindole] was described. A series of unprecedented 1, 3-dipoles were obtained by …