Function and therapeutic value of astrocytes in neurological diseases
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
[HTML][HTML] Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation
B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …
healthy and diseased brain. As a result, there is a large body of evidence that associates …
[HTML][HTML] NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches
Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …
defense mechanisms as well as physiological functions, and intracellular signaling …
[HTML][HTML] Inflammation context in Alzheimer's disease, a relationship intricate to define
C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological Research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …
Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
Astrocytes: key regulators of neuroinflammation
E Colombo, C Farina - Trends in immunology, 2016 - cell.com
Astrocytes are crucial regulators of innate and adaptive immune responses in the injured
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
central nervous system. Depending on timing and context, astrocyte activity may exacerbate …
Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell …
K Zhang, M Tu, W Gao, X Cai, F Song, Z Chen… - Nano …, 2019 - ACS Publications
Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …
[HTML][HTML] TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects
L Probert - Neuroscience, 2015 - Elsevier
Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …
defense and inflammatory responses but under certain circumstances also triggers cell …
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression
Previous studies have demonstrated a close association between an altered immune
system and major depressive disorders, and inhibition of neuroinflammation may represent …
system and major depressive disorders, and inhibition of neuroinflammation may represent …
[HTML][HTML] Diabetes and the brain: oxidative stress, inflammation, and autophagy
Diabetes mellitus is a common metabolic disorder associated with chronic complications
including a state of mild to moderate cognitive impairment, in particular psychomotor slowing …
including a state of mild to moderate cognitive impairment, in particular psychomotor slowing …