Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes.
Processes including myelination and synaptogenesis occur rapidly across the first 2–3 years …

White matter makes up about fifty percent of the human brain. Maturation of white matter
accompanies biological development and undergoes the most dramatic changes during …

Noninvasively mapping the layout of cortical areas in humans is a continuing challenge for
neuroscience. We present a new method of mapping cortical areas based on myelin content …

Through dynamic transactional processes between genetic and environmental factors,
childhood and adolescence involve reorganization and optimization of the cerebral cortex …

Despite recent advancements in MR imaging, non-invasive mapping of myelin in the brain
still remains an open issue. Here we attempted to provide a potential solution. Specifically …

MYELINATION is critical for the functional development of the brain, but the time course of
myelination during childhood is not well known. Diffusion tensor MR imaging (DTI) provides …

Human and non-human primate data suggest that the structural integrity of myelin sheaths
deteriorates during normal aging, especially in the late-myelinating association regions and …

OBJECTIVE: Myelination of the human brain results in roughly quadratic trajectories of
myelin content and integrity, reaching a maximum in mid-life and then declining in older age …

BACKGROUND: Postmortem and volumetric imaging data suggest that brain myelination is
a dynamic lifelong process that, in vulnerable late-myelinating regions, peaks in middle age …

MRI plays a central role in the diagnosis of multiple sclerosis (MS) and in the monitoring of
disease course and treatment response. Advanced MRI techniques have shed light on MS …