Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

Cells typically respond quickly to stress, altering their metabolism to compensate. In
mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis …

Multivalent biopolymers phase separate into membrane-less organelles (MLOs) which
exhibit liquid-like behavior. Here, we explore formation of prototypical MOs from multivalent …

The coordinated growth of cells and their organelles is a fundamental and poorly
understood problem, with implications for processes ranging from embryonic development …

Just as organ size typically increases with body size, the size of intracellular structures
changes as cells grow and divide. Indeed, many organelles, such as the nucleus [1, 2] …

The nucleolus is the site of ribosome biogenesis, one of the most resource-intensive
processes in eukaryotic cells. Accordingly, nucleolar morphology and activity are highly …

Background: It is common to find substantial Alzheimer disease (AD) lesions, ie, neuritic β-
amyloid plaques and neurofibrillary tangles, in the autopsied brains of elderly subjects with …

The pathologic changes of Alzheimer disease (AD) evolve very gradually over decades
before the disease becomes clinically manifest. Thus, it is not uncommon to find substantial …

The post-translational modification of proteins is critical for the spatial and temporal
regulation of signalling cascades. This is especially important in the CNS where the …

Cells have developed ways to sense and control the size of their organelles. Size-sensing
mechanisms range from direct measurements provided by dedicated reporters to indirect …