p38 Molecular Targeting for Next-Generation Multiple Myeloma Therapy

M Morales-Martínez, MI Vega - Cancers, 2024 - mdpi.com
Simple Summary In the last two decades, the use of small molecules as chemical inhibitors
of different targets in signaling pathways has been of great interest for therapeutic purposes …

Advances in research on potential inhibitors of multiple myeloma

G Tang, S Huang, J Luo, Y Wu, S Zheng, R Tong… - European Journal of …, 2023 - Elsevier
Multiple myeloma (MM) is a common hematological malignancy. Although recent clinical
applications of immunomodulatory drugs, proteasome inhibitors and CD38-targeting …

Mechanism of immunomodulatory drug resistance and novel therapeutic strategies in multiple myeloma

X Zuo, D Liu - Hematology, 2022 - Taylor & Francis
Objective The mechanism of immunomodulatory drugs (IMiDs) resistance to multiple
myeloma (MM) cells has been gradually demonstrated by recently studies, and some …

A multiomics disease progression signature of low-risk ccRCC

P Strauss, M Rivedal, A Scherer, Ø Eikrem… - Scientific Reports, 2022 - nature.com
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of
ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a …

TAK1-inhibitors did not reduce disease burden in a Vκ* MYC model of multiple myeloma

E Håland, IN Moen, EN Vandsemb, KK Starheim - BMC Research Notes, 2022 - Springer
Objective Multiple myeloma is a haematological malignancy characterized by proliferation of
monoclonal plasma cells in the bone marrow. Development of resistance and minimal …

p38 MAPK Molecular Targeting for Next-Generation Multiple Myeloma Therapy

M Morales-Martinez, MI Vega - 2024 - preprints.org
Resistance to therapy and disease progression are the main causes of mortality in most
cancers. In particular, the development of resistance is an important limitation affecting the …

Main genes in breast cancer primary tumor and first metastasis in lymph nodes revealed by information-theory-based genetic networks analysis

I Martínez-Vargas, M León-Pineda… - 2023 - researchsquare.com
In this paper we identify genes that could be principal in breast cancer primary tumor and its
firstmetastasis in lymph nodes, within biopsies in GEO and GDCDP database. By applying …