Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and
endothelia. Recently, we have shown that the human CAV-1 gene is localized to a …

Lipid rafts are cholesterol-and sphingolipid-enriched microdomains in cell membranes that
regulate phosphorylation cascades originating from membrane-bound proteins. In this study …

Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane
in endothelial and epithelial cells (14). Prior to the development of biochemical methods for …

During development and tissue homeostasis, patterns of cellular organization, proliferation
and movement are highly choreographed. Receptor tyrosine kinases (RTKs) have a crucial …

Abstract Three-dimensional (3D) cell culture techniques are frequently used to model
alterations in tissue architecture critically important for tumor development. Here, we report …

Caveolae are 50-to 100-nm omega-shaped invaginations of the plasma membrane that
function as regulators of signal transduction. Caveolins are a class of oligomeric structural …

Growth factors enable cells to escape irradiation-induced death (apoptosis). One important
family of growth factors share an epidermal growth factor motif, and all bind to ErbB …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Transforming growth factor-β (TGF-β) signaling proceeds from the cell membrane to the
nucleus through the cooperation of the type I and II serine/threonine kinase receptors and …