Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

We report the discovery of sulanemadlin (ALRN-6924), the first cell-permeating, stabilized α-
helical peptide to enter clinical trials. ALRN-6924 is a “stapled peptide” that mimics the N …

Engineered nanomaterials have been extensively employed as therapeutics for tumor
management. Meanwhile, the complex tumor niche along with multiple barriers at the …

Conspectus Biomolecules such as peptides, proteins, and nucleic acids generally cannot
cross a cell membrane by passive diffusion. Nevertheless, cell-penetrating peptides (CPPs) …

In recent decades, peptides, which can possess high potency, excellent selectivity, and low
toxicity, have emerged as promising therapeutics for cancer applications. Combined with an …

In the 20 years since the first report of a proteolysis targeting chimeric (PROTAC) molecule,
targeted protein degradation (TPD) technologies have attempted to revolutionize the fields …

Proximity-based strategies to degrade proteins have enormous therapeutic potential in
medicine, but the technologies are limited to proteins for which small molecule ligands exist …

Cytosolic delivery of peptides remains a challenging task because of the limited binding
sites on peptides and the existence of multiple intracellular barriers. Here, we proposed the …

As the landscape of macromolecule therapeutics advances, drug developers are continuing
to aim at intracellular targets. To activate, inhibit, or degrade these targets, the …