Cardiomyocyte maturation: new phase in development

Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

[HTML][HTML] Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects

G Paradies, V Paradies, FM Ruggiero, G Petrosillo - Cells, 2019 - mdpi.com
In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

[HTML][HTML] Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease

PH Reddy, DMA Oliver - Cells, 2019 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. Several decades of intense research have …

[HTML][HTML] The functional impact of mitochondrial structure across subcellular scales

B Glancy, Y Kim, P Katti, TB Willingham - Frontiers in physiology, 2020 - frontiersin.org
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Emerging diversity in lipid–protein interactions

V Corradi, BI Sejdiu, H Mesa-Galloso… - Chemical …, 2019 - ACS Publications
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome

MJ Barrera, S Aguilera, I Castro, P Carvajal, D Jara… - Autoimmunity …, 2021 - Elsevier
Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

[HTML][HTML] Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function

CS Field, F Baixauli, RL Kyle, DJ Puleston… - Cell metabolism, 2020 - cell.com
Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are
changes in lipid metabolism that support their survival and function. Fatty acid binding …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Determinants, maintenance, and function of organellar pH

SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Structure and mechanism of respiratory III–IV supercomplexes in bioenergetic membranes

P Brzezinski, A Moe, P Adelroth - Chemical reviews, 2021 - ACS Publications
In the final steps of energy conservation in aerobic organisms, free energy from electron
transfer through the respiratory chain is transduced into a proton electrochemical gradient …