Cardiomyocyte maturation: new phase in development
Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
[HTML][HTML] Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects
G Paradies, V Paradies, FM Ruggiero, G Petrosillo - Cells, 2019 - mdpi.com
In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …
processes that are vital for cell survival. Phospholipids are the main building blocks of …
[HTML][HTML] Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease
PH Reddy, DMA Oliver - Cells, 2019 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. Several decades of intense research have …
memory loss and multiple cognitive impairments. Several decades of intense research have …
[HTML][HTML] The functional impact of mitochondrial structure across subcellular scales
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …
mitochondria varies from cell to cell depending on the relative demands for energy …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: Potential role in Sjögren's syndrome
MJ Barrera, S Aguilera, I Castro, P Carvajal, D Jara… - Autoimmunity …, 2021 - Elsevier
Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …
inflammation, but few studies address the contribution of mitochondria and mitochondria …
[HTML][HTML] Mitochondrial integrity regulated by lipid metabolism is a cell-intrinsic checkpoint for Treg suppressive function
CS Field, F Baixauli, RL Kyle, DJ Puleston… - Cell metabolism, 2020 - cell.com
Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are
changes in lipid metabolism that support their survival and function. Fatty acid binding …
changes in lipid metabolism that support their survival and function. Fatty acid binding …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Structure and mechanism of respiratory III–IV supercomplexes in bioenergetic membranes
P Brzezinski, A Moe, P Adelroth - Chemical reviews, 2021 - ACS Publications
In the final steps of energy conservation in aerobic organisms, free energy from electron
transfer through the respiratory chain is transduced into a proton electrochemical gradient …
transfer through the respiratory chain is transduced into a proton electrochemical gradient …