The survey summarizes in its first part the current status of knowledge on the Congenital
Disorders of Glycosylation (CDG) with regard to their phenotypic spectrum, diagnostic and …

Capillary electrophoresis has emerged as a powerful approach for carbohydrate analyses
since 2014. The method provides high resolution capable of separating carbohydrates by …

This article illustrates the basis and applications of methodologies for the analysis of simple
and complex carbohydrates by means of CE. After a description of the most common and …

Congenital disorders of glycosylation (CDG) are a group of genetic disorders that affect
protein and lipid glycosylation and glycosylphosphatidylinositol synthesis. More than 100 …

N-Glycosylation is a fundamentally important protein modification with a major impact on
glycoprotein characteristics such as serum half-life and receptor interaction. More than half …

Facilitated by substantial advances in analytical methods, plasma N-glycans have emerged
as potential candidates for biomarkers. In the recent years, several investigations could link …

Metabolism not only produces energy necessary for the cell but is also a key regulator of
several cellular functions, including pluripotency and self-renewal. Nucleotide sugars (NSs) …

The glycome of one of the largest and most exposed human organs, the skin, as well as
glycan changes associated with non-melanoma skin cancers have not been studied in detail …

Background Mutations in the PMM2 gene cause phosphomannomutase 2 deficiency
(PMM2; MIM# 212065), which manifests as a congenital disorder of glycosylation (PMM2 …

As the roles of glycans in health and disease continue to be unraveled, it is becoming
apparent that glycans' immense complexity cannot be ignored. To fully delineate glycan …