Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Z Younossi, QM Anstee, M Marietti, T Hardy… - Nature reviews …, 2018 - nature.com
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …

Origins of lifetime health around the time of conception: causes and consequences

TP Fleming, AJ Watkins, MA Velazquez, JC Mathers… - The Lancet, 2018 - thelancet.com
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

Hepatic stellate cells as key target in liver fibrosis

T Higashi, SL Friedman, Y Hoshida - Advanced drug delivery reviews, 2017 - Elsevier
Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

LA Adams, QM Anstee, H Tilg, G Targher - Gut, 2017 - gut.bmj.com
Key physiological functions of the liver, including glucose and lipid metabolism, become
disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated …

Noninvasive Diagnosis of NAFLD and NASH

VA Piazzolla, A Mangia - Cells, 2020 - mdpi.com
The aim of this review is to outline emerging biomarkers that can serve as early diagnostic
tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic …

[PDF][PDF] Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

ZM Younossi, R Loomba, QM Anstee, ME Rinella… - …, 2018 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a spectrum comprised of isolated steatosis,
nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. The majority of …

Nonalcoholic fatty liver disease

EM Brunt, VWS Wong, V Nobili, CP Day… - Nature reviews Disease …, 2015 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a disorder characterized by excess accumulation
of fat in hepatocytes (nonalcoholic fatty liver (NAFL)); in up to 40% of individuals, there are …

The organoid cell atlas

C Bock, M Boutros, JG Camp, L Clarke, H Clevers… - Nature …, 2021 - nature.com
To the Editor—Human organoids hold tremendous potential for biomedical applications 1–3
(Fig. 1a, b). These three-dimensional structures of cultured cells recapitulate important …