It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

Platelets are known for their role in haemostasis where they help prevent blood loss at sites
of vascular injury. To do this, they adhere, aggregate and form a procoagulant surface …

Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation and
reduced apoptosis of pulmonary artery smooth muscle cells (PASMCs). Because …

Progression of pulmonary hypertension is associated with increased proliferation and
migration of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and …

The heart responds to injury and chronic pressure overload by pathologic growth and
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

The transient receptor potential (TRP1) ion channels are named after the role of the
channels in Drosophila phototransduction. The mammalian genes are encoded by at least …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …