III. IGFs and Their Receptors A. IGF peptides and receptors B. Expression of IGFs and IGF
receptors in the ovary C. Role of IGFs in ovulatory function and steroidogenesis

Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a
central role in maintaining basic cellular functions such as growth, survival, and metabolism …

Type 2 diabetes is characterized by abnormalities of insulin action in muscle, adipose tissue,
and liver and by altered β-cell function. To analyze the role of the insulin signaling pathway …

Diabetes Branch target organ is the most important site of insulin resis-Division of Intramural
Research tance: skeletal muscle, adipose tissue, or liver? Fortu-National Institute of …

Since the first edition of this highly acclaimed text was published in 1992, much new
knowledge has been gained about the role of genetic factors in common adult diseases, and …

At least eight distinct pathophysiologic abnormalities have been associated with type 2
diabetes mellitus (T2DM). It is well established that decreased peripheral glucose uptake …

To examine contributions of specific YXXM motifs in human insulin receptor substrate-1 (IRS-
1) to mediating the metabolic actions of insulin, we studied IRS-1 mutants containing various …

Normoglycemic subjects with a strong family history of type 2 diabetes are insulin resistant,
but the mechanism of insulin resistance in skeletal muscle of such individuals is unknown …

Aims/hypothesis Several case-control studies have examined the association between the
Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and …

Biologically active proteins without stable tertiary structure are common in all known
proteomes. Functions of these intrinsically disordered proteins (IDPs) are typically related to …