The evolving erythrocyte: red blood cells as modulators of innate immunity

HL Anderson, IE Brodsky… - The Journal of …, 2018 - journals.aai.org
The field of red cell biology is undergoing a quiet revolution. Long assumed to be inert
oxygen carriers, RBCs are emerging as important modulators of the innate immune …

Mitochondrial lactate metabolism: history and implications for exercise and disease

B Glancy, DA Kane, AN Kavazis… - The Journal of …, 2021 - Wiley Online Library
Mitochondrial structures were probably observed microscopically in the 1840s, but the idea
of oxidative phosphorylation (OXPHOS) within mitochondria did not appear until the 1930s …

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

J Mengel-From, M Thinggaard, C Dalgård, KO Kyvik… - Human genetics, 2014 - Springer
The role of the mitochondria in disease, general health and aging has drawn much attention
over the years. Several attempts have been made to describe how the numbers of …

Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance

K Salin, SK Auer, B Rey… - Proceedings of the …, 2015 - royalsocietypublishing.org
It is often assumed that an animal's metabolic rate can be estimated through measuring the
whole-organism oxygen consumption rate. However, oxygen consumption alone is unlikely …

[HTML][HTML] The chicken embryo model: A novel and relevant model for immune-based studies

P Garcia, Y Wang, J Viallet… - Frontiers in immunology, 2021 - frontiersin.org
Dysregulation of the immune system is associated with many pathologies, including
cardiovascular diseases, diabetes, and cancer. To date, the most commonly used models in …

What maintains signal honesty in animal colour displays used in mate choice?

RJ Weaver, RE Koch, GE Hill - … Transactions of the …, 2017 - royalsocietypublishing.org
Many of the colour displays of animals are proposed to have evolved in response to female
mate choice for honest signals of quality, but such honest signalling requires mechanisms to …

Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance

HE Morales, A Pavlova, L Joseph… - Molecular …, 2015 - Wiley Online Library
Diversifying selection on metabolic pathways can reduce intraspecific gene flow and
promote population divergence. An opportunity to explore this arises from mitonuclear …

Increased glucocorticoid concentrations in early life cause mitochondrial inefficiency and short telomeres

S Casagrande, A Stier, P Monaghan… - Journal of …, 2020 - journals.biologists.com
Telomeres are DNA structures that protect chromosome ends. However, telomeres shorten
during cell replication and at critically low lengths can reduce cell replicative potential …

Stress hypothesis overload: 131 hypotheses exploring the role of stress in tradeoffs, transitions, and health

BN Harris - General and Comparative Endocrinology, 2020 - Elsevier
Stress is ubiquitous and thus, not surprisingly, many hypotheses and models have been
created to better study the role stress plays in life. Stress spans fields and is found in the …

Evolution and genetic architecture of sex-limited polymorphism in cuckoos

J Merondun, CI Marques, P Andrade… - Science …, 2024 - science.org
Sex-limited polymorphism has evolved in many species including our own. Yet, we lack a
detailed understanding of the underlying genetic variation and evolutionary processes at …