Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system.
NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs …

The biology of peroxisome proliferator activated receptors (PPARs) in physiological and
pathophysiological processes has been primarily studied in peripherial organs and tissues …

The peroxisome proliferator activated receptor gamma (PPARγ) is a member in the nuclear
receptor superfamily which mediates part of the regulatory effects of dietary fatty acids on …

Neurodegeneration is one of the driving forces behind the pathogenesis of multiple sclerosis
(MS). Progression without activity, pathopsychological disturbances (cognitive impairment …

15-deoxy-Δ12, 14-prostagandin J2 (15d-PGJ2) is produced in the inflamed cells and tissues
as a consequence of upregulation of cyclooxygenase-2 (COX-2). 15d-PGJ2 is known to be …

Multiple sclerosis (MS) is marked by neuroinflammation and demyelination with loss of
oligodendrocytes in the central nervous system. The immune response is regulated by …

Central nervous system (CNS) is an immune privileged site, nevertheless inflammation
associates with many CNS diseases. Peroxisome proliferator‐activated receptors (PPARs) …

Increasing data demonstrates that inflammation participates in the pathophysiology of
neurodegenerative diseases. Among the different inflammatory mediators involved …

In the recent years, the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), a well known
target for type II diabetes treatment, has received an increasing attention for its therapeutic …

Background Inflammation is known to play a pivotal role in mediating neuronal damage and
axonal injury in a variety of neurodegenerative disorders. Among the range of inflammatory …