Viral genome packaging machines: Structure and enzymology
CE Catalano, MC Morais - The Enzymes, 2021 - Elsevier
Although the process of genome encapsidation is highly conserved in tailed bacteriophages
and eukaryotic double-stranded DNA viruses, there are two distinct packaging pathways that …
and eukaryotic double-stranded DNA viruses, there are two distinct packaging pathways that …
Controlling the revolving and rotating motion direction of asymmetric hexameric nanomotor by arginine finger and channel chirality
Nanomotors in nanotechnology are as important as engines in daily life. Many ATPases are
nanoscale biomotors classified into three categories based on the motion mechanisms in …
nanoscale biomotors classified into three categories based on the motion mechanisms in …
Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor
Double-stranded DNA viruses package their genomes into pre-assembled capsids using
virally-encoded ASCE ATPase ring motors. We present the first atomic-resolution crystal …
virally-encoded ASCE ATPase ring motors. We present the first atomic-resolution crystal …
Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system
HKH Fung, S Grimes, A Huet, RL Duda… - Nucleic acids …, 2022 - academic.oup.com
Many essential cellular processes rely on substrate rotation or translocation by a multi-
subunit, ring-type NTPase. A large number of double-stranded DNA viruses, including tailed …
subunit, ring-type NTPase. A large number of double-stranded DNA viruses, including tailed …
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation
Many viruses utilize ringed packaging ATPases to translocate double-stranded DNA into
procapsids during replication. A critical step in the mechanochemical cycle of such ATPases …
procapsids during replication. A critical step in the mechanochemical cycle of such ATPases …
Functional dissection of a viral DNA packaging Machine's Walker B Motif
Many viruses employ ATP-powered motors for genome packaging. We combined genetic,
biochemical, and single-molecule techniques to confirm the predicted Walker-B ATP-binding …
biochemical, and single-molecule techniques to confirm the predicted Walker-B ATP-binding …
Phenanthridine derivatives as potential HIV‑1 protease inhibitors
PV Ershov, YV Мezentsev… - Biomedical …, 2020 - spandidos-publications.com
In the present study, the antiviral activity of phenanthridine derivatives was assessed. In
total, the inhibitory effect of eight structurally similar low‑molecular‑weight hydrophobic …
total, the inhibitory effect of eight structurally similar low‑molecular‑weight hydrophobic …
Molecular dynamics of DNA translocation by FtsK
The bacterial FtsK motor harvests energy from ATP to translocate double-stranded DNA
during cell division. Here, we probe the molecular mechanisms underlying coordinated DNA …
during cell division. Here, we probe the molecular mechanisms underlying coordinated DNA …
Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction
Many viruses utilize ATP-powered motors to package DNA into viral capsids. Here we use
single DNA manipulation with optical tweezers and rapid solution exchange to interrogate …
single DNA manipulation with optical tweezers and rapid solution exchange to interrogate …
ATP serves as a nucleotide switch coupling the genome maturation and packaging motor complexes of a virus assembly machine
Q Yang, CE Catalano - Nucleic Acids Research, 2020 - academic.oup.com
The assembly of double-stranded DNA viruses, from phages to herpesviruses, is strongly
conserved. Terminase enzymes processively excise and package monomeric genomes …
conserved. Terminase enzymes processively excise and package monomeric genomes …