The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

This review is provided in recognition of the extensive contributions of Dr. Robert J.
Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday …

In 2012, preliminary guidelines were published addressing sample quality, data acquisition
and reduction, presentation of scattering data and validation, and modelling for biomolecular …

Small-angle scattering of X-rays (SAXS) is an established method to study the overall
structure and structural transitions of biological macromolecules in solution. For folded …

Highlights•Intrinsically disordered proteins mostly function by molecular recognition.•Post-
translational modifications regulate the interactions of IDPs.•Structural disorder can facilitate …

An approach combining small-angle X-ray solution scattering (SAXS) data with coarse-
grained (CG) simulations is developed to characterize the assembly states of Hck, a member …

Proteins provide much of the scaffolding for life, as well as undertaking a variety of essential
catalytic reactions. These characteristic functions have led us to presuppose that proteins …

The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module
present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is …

Structural disorder is an essential ingredient for function in many proteins and protein
complexes. Fuzzy complexes describe the many instances where disorder is maintained as …

Multidomain proteins in which consecutive globular regions are connected by linkers are
prevalent in nature (Levitt in Proc Natl Acad Sci USA 106: 11079–11084, 2009). Some …