The skeleton is the framework and in charge of body configuration preservation. As a living
tissue, bones are constantly being formed and absorbed. Osteoblasts and osteoclasts are …

Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by a
deficiency in lysosomal enzymes catalyzing the stepwise degradation of …

The present study tested whether activation of the sympathetic tone by aberrant joint loading
elicits abnormal subchondral bone remodeling in temporomandibular joint (TMJ) …

Altered BM hematopoiesis and immune suppression are hallmarks of myelodysplastic
syndrome (MDS). While the BM microenvironment influences malignant hematopoiesis, the …

Mesenchymal stromal cells (MSCs) are crucial elements in the bone marrow (BM) niche
where they provide physical support and secrete soluble factors to control and maintain …

Summary Background Mucopolysaccharidoses (MPSs) are rare genetic diseases caused by
a deficient activity of one of the lysosomal enzymes involved in the glycosaminoglycan …

Background aims Cord blood (CB) and amniotic fluid (AF) could represent new and
attractive mesenchymal stromal cell (MSC) sources, but their potential therapeutic …

The need for immunosuppression after allo/xenogenic mesenchymal stromal cell (MSC)
transplantation is debated. This study compared the long-term effects of human (h) bone …

Progressive skeletal and connective tissue disease represents a significant clinical burden
in all of the mucopolysaccharidoses. Despite the introduction of enzyme replacement …

Inborn errors of metabolism (IEM) are a group of rare, heterogenous diseases caused mostly
by monogenic mutations that result in disruption of metabolic pathways due to deficient …