Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

The endothelial cells that compose the vascular system in the body display a wide range of
mechanotransductive behaviors and responses to biomechanical stimuli, which act in …

A wide variety of animal models have been used to study glaucoma. Although these models
provide valuable information about the disease, there is still no ideal model for studying …

The purpose of this report is to summarize the current strengths and weaknesses of the non-
human primate (NHP) experimental glaucoma (EG) model through sections devoted to its …

Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence
derived from experimental studies in primates and rodents strongly indicates that the site of …

In a series of previous publications we have proposed a framework for conceptualizing the
optic nerve head (ONH) as a biomechanical structure. That framework proposes important …

We investigate the role of glial cell activation in the human optic nerve caused by raised
intraocular pressure, and their potential role in the development of glaucomatous optic …

Microglial cells are the resident macrophages of the central nervous system. Their function is
essential for neuronal tissue homeostasis. After inflammatory stimuli, microglial cells …

Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation,
migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies …

Nerve axonal injury and associated cellular mechanisms leading to peripheral nerve
damage are important topics of research necessary for reducing disability and enhancing …