The nature of immune responses to urinary tract infections

SN Abraham, Y Miao - Nature Reviews Immunology, 2015 - nature.com
The urinary tract is constantly exposed to microorganisms that inhabit the gastrointestinal
tract, but generally the urinary tract resists infection by gut microorganisms. This resistance …

[HTML][HTML] Gut dysbiosis in animals due to environmental chemical exposures

CS Rosenfeld - Frontiers in cellular and infection microbiology, 2017 - frontiersin.org
The gut microbiome consists of over 103–104 microorganism inhabitants that together
possess 150 times more genes that the human genome and thus should be considered an …

Microbiome disturbances and autism spectrum disorders

CS Rosenfeld - Drug Metabolism and Disposition, 2015 - ASPET
Autism spectrum disorders (ASDs) are considered a heterogenous set of neurobehavioral
diseases, with the rates of diagnosis dramatically increasing in the past few decades. As …

The immune response to infection in the bladder

L Lacerda Mariano, MA Ingersoll - Nature Reviews Urology, 2020 - nature.com
The bladder is continuously protected by passive defences such as a mucus layer,
antimicrobial peptides and secretory immunoglobulins; however, these defences are …

Drug and vaccine development for the treatment and prevention of urinary tract infections

VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …

Антимикробная терапия и профилактика инфекций почек, мочевыводящих путей и мужских половых органов. Федеральные клинические рекомендации

ТС Перепанова, РС Козлов, ВА Руднов, ЛА Синякова - 2017 - elibrary.ru
Инфекционно-воспалительные урологические осложнения и заболевания
представляют сложную проблему, как для диагностики, так и для лечения. Частота …

[HTML][HTML] Immunomodulation therapy offers new molecular strategies to treat UTI

D Butler, I Ambite, MLY Wan, TH Tran, B Wullt… - Nature Reviews …, 2022 - nature.com
Innovative solutions are needed for the treatment of bacterial infections, and a range of
antibacterial molecules have been explored as alternatives to antibiotics. A different …

[HTML][HTML] Human microbiota characterization in the course of renal transplantation

WF Fricke, C Maddox, Y Song, JS Bromberg - American Journal of …, 2014 - Elsevier
Recent studies demonstrate that the human microbiota, the collection of microorganisms
growing on and in individuals, have numerous bidirectional interactions with the host …

[HTML][HTML] Innate immunity and genetic determinants of urinary tract infection susceptibility

G Godaly, I Ambite, C Svanborg - Current opinion in infectious …, 2015 - journals.lww.com
It is time to start using genetics in UTI-prone patients, to improve diagnosis and to assess the
risk for chronic sequels such as renal malfunction, hypertension, spontaneous abortions …

A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer

DSC Butler, C Cafaro, J Putze, MLY Wan… - Nature …, 2021 - nature.com
Is the oncogene MYC upregulated or hyperactive? In the majority of human cancers, finding
agents that target c-MYC has proved difficult. Here we report specific bacterial effector …