New psychoactive substances (NPS) are a heterogeneous group of substances. They are
associated with a number of health and social harms on an individual and societal level …

Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Tandem mass spectrometry–especially in combination with liquid chromatography (LC–
MS/MS)–is applied in a multitude of important diagnostic niches of laboratory medicine. It is …

Background In 2016, the number of overdose deaths involving illicitly-manufactured fentanyl
(IMF) surpassed heroin and prescription opioid deaths in the United States for the first time …

Abstract Background British Columbia, Canada, is experiencing a public health emergency
related to opioid overdoses driven by consumption of street drugs contaminated with illicitly …

Background Illicitly manufactured fentanyl and its analogues are appearing in countries
throughout the world, often disguised as heroin or counterfeit prescription pills, with resulting …

The concept of bioisosterism and the implementation of bioisosteric replacement is
fundamental to medicinal chemistry. The exploration of bioisosteres is often used to probe …

BACKGROUND Since 2013, an unprecedented surge in fentanyl overdose deaths has been
caused by heroin laced with illicitly produced fentanyl and/or fentanyl analogs (FAs) sold as …