Recombinant porcine lactoferrin expressed in the milk of transgenic mice enhances offspring growth performance

SC Wu, HL Chen, CC Yen, MF Kuo… - Journal of Agricultural …, 2007 - ACS Publications
The European Commission has proposed a permanent ban on the use of antibiotics as an
ingredient in animal feed to promote growth. Lactoferrin is a globular multifunctional protein …

High level expression of tissue-nonspecific alkaline phosphatase in the milk of transgenic rabbits

L Bodrogi, R Brands, W Raaben, W Seinen… - Transgenic …, 2006 - Springer
Alkaline phosphatase is a promising therapeutic agent in the Gram-negative bacterial
lipopolysaccharide (LPS) mediated acute and chronic diseases. Contrary to other alkaline …

The high-level expression of human tissue plasminogen activator in the milk of transgenic mice with hybrid gene locus strategy

Y Zhou, Y Lin, X Wu, F Xiong, Y Lv, T Zheng… - Molecular …, 2012 - Springer
Transgene expression for the mammary gland bioreactor aimed at producing recombinant
proteins requires optimized expression vector construction. Previously we presented a …

A mWAP–hLF hybrid gene locus gave extremely high level expression of human lactoferrin in the milk of transgenic mice

G Shi, H Chen, X Wu, Y Zhou, Z Liu, T Zheng… - Transgenic …, 2009 - Springer
The production of pharmaceuticals by current mammary gland bioreactor techniques is
limited by the low expression level of foreign proteins. We describe here a novel method that …

Isolation and some effects of functional, low-phenylalanine κ-casein expressed in the milk of transgenic rabbits

M Baranyi, L Hiripi, L Szabó, AP Catunda… - Journal of …, 2007 - Elsevier
Patients suffering certain metabolic diseases (eg phenylketonuria) need a low-
phenylalanine diet throughout their lives. Transgenic rabbits were created to express low …

Design of vectors for transgene expression: The use of genomic comparative approaches

L Montoliu, R Roy, L Regales, Á García-Díaz - … , microbiology and infectious …, 2009 - Elsevier
The design of transgenes has always been limited by the extent of available information on
the endogenous locus whose expression pattern had to be replicated. Those genes whose …

Genomic insulators in transgenic animals

E Moltó, C Vicente-García, A Fernández… - Mouse as a Model …, 2011 - Springer
Vertebrate genomes are functionally and structurally organised as gene expression
domains. These domains contain all regulatory elements required for the gene (or genes) to …

Rabbit milk protein genes: from mRNA identification to chromatin structure

G Jolivet, N Daniel-Carlier, D Thépot, S Rival-Gervier… - animal, 2008 - cambridge.org
Milk protein genes are among the most intensively expressed and they are active only in
epithelial mammary cells of lactating animals. They code for proteins which represent 30 …

Organisation nucléaire et expression des gènes des protéines du lait

E Chanat, E Aujean, A Balteanu, S Chat… - Journal de la Société …, 2006 - biologie-journal.org
L'expression des gènes codant les protéines du lait varie au cours de la gestation/lactation.
Elle est notamment régulée par les hormones lactogènes qui induisent une activation de …