Kv3 channels: enablers of rapid firing, neurotransmitter release, and neuronal endurance
LK Kaczmarek, Y Zhang - Physiological reviews, 2017 - journals.physiology.org
The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …
channels they express. From among the more than 70 different K+ channel genes …
[HTML][HTML] Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity
H Kuba, R Yamada, G Ishiguro, R Adachi - Nature communications, 2015 - nature.com
Structural plasticity of the axon initial segment (AIS), the trigger zone of neurons, is a
powerful means for regulating neuronal activity. Here, we show that AIS plasticity is not …
powerful means for regulating neuronal activity. Here, we show that AIS plasticity is not …
Potassium channel modulation and auditory processing
MR Brown, LK Kaczmarek - Hearing research, 2011 - Elsevier
For accurate processing of auditory information, neurons in auditory brainstem nuclei have
to fire at high rates with high temporal accuracy. These two requirements can only be fulfilled …
to fire at high rates with high temporal accuracy. These two requirements can only be fulfilled …
[HTML][HTML] Acoustic over-exposure triggers burst firing in dorsal cochlear nucleus fusiform cells
N Pilati, C Large, ID Forsythe, M Hamann - Hearing research, 2012 - Elsevier
Acoustic over-exposure (AOE) triggers deafness in animals and humans and provokes
auditory nerve degeneration. Weeks after exposure there is an increase in the cellular …
auditory nerve degeneration. Weeks after exposure there is an increase in the cellular …
Modulators of Kv3 potassium channels rescue the auditory function of fragile X mice
Fragile X syndrome (FXS) is characterized by hypersensitivity to sensory stimuli, including
environmental sounds. We compared the auditory brainstem response (ABR) recorded in …
environmental sounds. We compared the auditory brainstem response (ABR) recorded in …
Modulation of potassium conductances optimizes fidelity of auditory information
LK Kaczmarek - Proceedings of the National Academy of …, 2023 - National Acad Sciences
Potassium channels in auditory neurons are rapidly modified by changes in the auditory
environment. In response to elevated auditory stimulation, short-term mechanisms such as …
environment. In response to elevated auditory stimulation, short-term mechanisms such as …
Redistribution of Kv2. 1 ion channels on spinal motoneurons following peripheral nerve injury
SH Romer, KM Dominguez, MW Gelpi, AS Deardorff… - Brain research, 2014 - Elsevier
Pathophysiological responses to peripheral nerve injury include alterations in the activity,
intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α …
intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α …
[HTML][HTML] Loud noise-exposure changes the firing frequency of subtypes of layer 5 pyramidal neurons and Martinotti cells in the mouse auditory cortex
Introduction Loud noise-exposure can generate noise-induced tinnitus in both humans and
animals. Imaging and in vivo studies show that noise exposure affects the auditory cortex; …
animals. Imaging and in vivo studies show that noise exposure affects the auditory cortex; …
Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell–motor neuron circuit
When activating muscles, motor neurons in the spinal cord also activate Renshaw cells,
which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with …
which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with …
Increased spontaneous firing rates in auditory midbrain following noise exposure are specifically abolished by a Kv3 channel modulator
LA Anderson, LL Hesse, N Pilati, WMH Bakay, G Alvaro… - Hearing research, 2018 - Elsevier
Noise exposure has been shown to produce long-lasting increases in spontaneous activity
in central auditory structures in animal models, and similar pathologies are thought to …
in central auditory structures in animal models, and similar pathologies are thought to …