The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …

Structural plasticity of the axon initial segment (AIS), the trigger zone of neurons, is a
powerful means for regulating neuronal activity. Here, we show that AIS plasticity is not …

For accurate processing of auditory information, neurons in auditory brainstem nuclei have
to fire at high rates with high temporal accuracy. These two requirements can only be fulfilled …

Acoustic over-exposure (AOE) triggers deafness in animals and humans and provokes
auditory nerve degeneration. Weeks after exposure there is an increase in the cellular …

Fragile X syndrome (FXS) is characterized by hypersensitivity to sensory stimuli, including
environmental sounds. We compared the auditory brainstem response (ABR) recorded in …

Potassium channels in auditory neurons are rapidly modified by changes in the auditory
environment. In response to elevated auditory stimulation, short-term mechanisms such as …

Pathophysiological responses to peripheral nerve injury include alterations in the activity,
intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α …

Introduction Loud noise-exposure can generate noise-induced tinnitus in both humans and
animals. Imaging and in vivo studies show that noise exposure affects the auditory cortex; …

When activating muscles, motor neurons in the spinal cord also activate Renshaw cells,
which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with …

Noise exposure has been shown to produce long-lasting increases in spontaneous activity
in central auditory structures in animal models, and similar pathologies are thought to …