Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the
selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …

Diabetic retinopathy (DR) is a major microvascular complication associated with type 1 and
type 2 diabetes mellitus, which can lead to visual impairment and blindness. Current …

Polyamidoamine (PAMAM) dendrimers are multi-branched, three-dimensional polymers
with unique architecture, which makes these molecules attractive for medical and …

BACKGROUND: Statins represent a class of drugs that effectively lowers cholesterol,
however they also possess pleiotropic effects, like promotion of angiogenesis, prevention of …

Background and Purpose The entire kallikrein–kinin system is present in the skin, and it is
thought to exert a relevant role in cutaneous diseases, including psoriasis. The present …

In the search for improved quality of life, the treatment of skin diseases like psoriasis
(hyperproliferative disease) is valid, since it causes huge social discomfort to the patient. In …

Previous studies have shown that all kinin system is constitutively expressed in the normal
and inflamed skin, with a potential role in both physiological and pathological processes …

Impaired skin wound healing is a major medical problem in diabetic subjects. Kinins exert a
number of vascular and other actions limiting organ damage in ischaemia or diabetes, but …

Kinins are a group of peptides derived from kininogens that participate importantly in
inflammatory and painful processes, modulating many physiological cellular functions …

Ethnopharmacological relevance Inflammatory skin diseases presents high prevalence and
lack of alternatives that can be used for self-care by the population. Casearia sylvestris is a …