The plasma membrane (PM) performs a plethora of physiological processes, the
coordination of which requires spatial and temporal organization into specialized domains of …

This review is focused on sphingolipid backbone hydroxylation, a small but widespread
structural feature with profound impact on membrane biophysical properties. We start by …

The lipid raft concept proposes that biological membranes have the potential to form
functional domains based on a selective interaction between sphingolipids and sterols …

The interaction between cholesterol and phospholipids in bilayer membranes is important
for the formation and maintenance of membrane structure and function. However …

Sphingomyelins are important phospholipids in plasma membranes of most cells. Because
of their dominantly saturated nature, they affect the lateral structure of membranes, and …

Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural
and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous …

The lipid bilayer of the plasma membrane is thought to be compartmentalized by the
presence of lipid-protein microdomains. In eukaryotic cells, microdomains composed of …

Plasma membrane carries out multiple physiological functions that require its dynamic and
tightly regulated organization into specialized domains of different size, stability, and …

Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) is a minor but ubiquitous component of
the inner leaflet of the plasma membrane of eukaryotic cells. However, due to its particular …

We have prepared palmitoyl sphingomyelin (PSM) analogs in which either the 2-NH was
methylated to NMe, the 3-OH was methylated to OMe, or both were methylated …