Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer
patients receiving chemotherapy. It is correlated with the collateral damage to renal cells …

Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization,
and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is) …

Acute kidney injury (AKI) is a sudden loss of kidney function that causes a rise in serum
creatinine and a decrease in urine output, which leads to high morbidity and mortality …

Objectives To investigate the protective effect of vanillin in cisplatin (CP)-induced
nephrotoxicity in rats and elucidate the role of nrf-2 and its downstream antioxidant …

Cardiotoxicity is an adverse effect of the anticancer drug doxorubicin (DOX). Gemfibrozil
(GEM) is a lipid-lowering drug with a number of biological properties such as anti …

The current work explored the influences of time dependent Sildenafil (SILD) administration,
and the possible outcomes from its concomitant administration with dexamethasone against …

Gemfibrozil (GFZ) is a medication of the fibrate category with agonistic effects on peroxisome
proliferator‐activated receptor‐α (PPAR‐α) and is effective for hypertriglyceridemia and …

Background The therapeutic utility of the effective chemotherapeutic agent cisplatin is
hampered by its nephrotoxic effect. We aimed from the current study to examine the possible …

OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is an important clinical problem
that can be aggravated by diabetes mellitus, a major risk factor. However, heme oxygenase …

Cisplatin dose-dependent nephrotoxicity is a major issue limiting its proper use in cancer
treatment. Inflammation, redox imbalance, and dysregulated cell death are the most …