High-valent metal–oxo species with multiply-bonded M–O groups have been proposed as
key intermediates in many biological and abiological catalytic oxidation reactions. These …

Utilization of O2 as an abundant and environmentally benign oxidant is of great interest in
the design of bioinspired synthetic catalytic oxidation systems. Metalloenzymes activate O2 …

This tutorial review showcases recent (2015–2021) work describing ligand construction as it
relates to the design of secondary coordination spheres (SCSs). Metalloenzymes, for …

In nature, nonheme iron enzymes use dioxygen to generate high-spin iron (IV)= O species
for a variety of oxygenation reactions. Although synthetic chemists have long sought to …

Activation of dinitrogen plays an important role in daily anthropogenic life, and the processes
by which this fixation occurs have been a longstanding and significant research focus within …

Enzymatic haem and non-haem high-valent iron–oxo species are known to activate strong C–
H bonds, yet duplicating this reactivity in a synthetic system remains a formidable challenge …

The rational design of well-defined, first-row transition metal complexes that can activate
dioxygen has been a challenging goal for the synthetic inorganic chemist. The activation of …

The development of catalysts for electrochemical reduction of carbon dioxide offers an
attractive approach to transforming this greenhouse gas into value-added carbon products …

High-valent iron-oxo intermediates have often been implicated, and in some cases
identified, as the active oxidant in oxygen activating nonheme iron enzymes. Recent …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …