For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in
response to stress. This response also involves other distinct morphological and intracellular …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

Simple Summary Senescence is an essential component of tumor cell biology and is a
primary cell stress response to therapy. While the long-term impact of senescence in cancer …

Combination therapy with BRAF and MEKi has evolved as a standard of care in the
treatment of locally advanced or metastatic BRAF V600-mutated melanoma. Despite …

Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

Macroautophagy (autophagy hereafter) may promote survival and growth of spontaneous
tumors, including melanoma. We utilized a genetically engineered mouse model of …

Oncogene-induced senescence, eg, in melanocytic nevi, terminates the expansion of pre-
malignant cells via transcriptional silencing of proliferation-related genes due to decoration …

Drug resistance constitutes a major challenge in designing melanoma therapies.
Microenvironment-driven tumor heterogeneity and plasticity play a key role in this …

Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an
indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged …