Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision

F Karamali, S Behtaj, S Babaei-Abraki… - Journal of translational …, 2022 - Springer
Photoreceptors (PRs), as the most abundant and light-sensing cells of the neuroretina, are
responsible for converting light into electrical signals that can be interpreted by the brain. PR …

Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair

F Mohebichamkhorami, Z Niknam, H Zali… - Stem Cell Reviews and …, 2023 - Springer
The retina has restricted regeneration ability to recover injured cell layer because of reduced
production of neurotrophic factors and increased inhibitory molecules against axon …

Electrospun PGS/PCL, PLLA/PCL, PLGA/PCL and pure PCL scaffolds for retinal progenitor cell cultivation

S Behtaj, F Karamali, E Masaeli, YG Anissimov… - Biochemical …, 2021 - Elsevier
Recent advances in cell transplantation technologies have shown that polymeric fibrous
tissue-engineered scaffolds provide a suitable physical environment, including the structural …

Retinal Organoid Models Show Heterozygous Rhodopsin Mutation Favors Endoplasmic Reticulum Stress-Induced Apoptosis in Rods

Q Yang, J Li, S Zeng, Z Li, X Liu, J Li… - Stem Cells and …, 2023 - liebertpub.com
Retinitis pigmentosa (RP) is a prevalent inherited retinal degenerative disease resulting
from photoreceptor and pigment epithelial apoptosis. The Rhodopsin (RHO) is the most …

The role of PGS/PCL scaffolds in promoting differentiation of human embryonic stem cells into retinal ganglion cells

S Behtaj, F Karamali, S Najafian, E Masaeli… - Acta Biomaterialia, 2021 - Elsevier
The stem cell-based retinal ganglion cells (RGCs) replacement therapy offers a potential to
restore vision in progressive optic neuropathies including glaucoma by replacing …

Scaffold free retinal pigment epithelium sheet engineering using modified alginate-RGD hydrogel

S Soroushzadeh, F Karamali, E Masaeli, A Atefi… - Journal of bioscience …, 2022 - Elsevier
Tissue-specific extracellular matrix (ECM) plays a critical role in cell survival and
homeostasis, which are particularly essential for directing differentiation of different complex …

PD-1 suppresses the osteogenic and odontogenic differentiation of stem cells from dental apical papilla via targeting SHP2/NF-κB Axis

N Li, Z Li, L Fu, M Yan, Y Wang, J Yu, J Wu - Stem Cells, 2022 - academic.oup.com
Stem cells from the apical papilla (SCAPs) are important for tooth root development and
regeneration of root dentin. Here, we examined the expression of programmed cell death …

The proliferative effects of stem cells from apical papilla‐conditioned medium on rat corneal endothelial cells

K Rahimiyan, MH Nasr Esfahani… - Wound Repair and …, 2024 - Wiley Online Library
The cornea, positioned at the forefront of the eye, refracts the light for focusing images on the
retina. Damage to this transparent structure can lead to various visual disorders. The corneal …

Integrated stem cells from apical papilla in a 3D culture system improve human embryonic stem cell derived retinal organoid formation

S Savoj, MHN Esfahani, A Karimi, F Karamali - Life Sciences, 2022 - Elsevier
Aim Eye organoids are 3D models of the retina that provide new possibilities for studying
retinal development, drug toxicity and the molecular mechanisms of diseases. Although …

Switchable phase transition behavior of thermoresponsive substrates for cell sheet engineering

K Mokhtarinia, MS Nourbakhsh… - Journal of Polymer …, 2018 - Wiley Online Library
Recently, there are significant interests in the development of biomaterials with nonlinear
response to an external stimulus. Thermoresponsive polymers as a well‐known class of …