Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal
monogenic disorder. It has large inter-and intra-familial variability explained to a large extent …

Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates
beneficial heterologous effects, but the mechanisms underlying its persistence and …

The biliary tract consists of a network of intrahepatic and extrahepatic ducts that collect and
drain the bile produced by hepatocytes to the gut. The bile ducts are lined by …

Background and objectives: Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor
that is critical for the development of kidney and pancreas. In humans, mutations in HNF1B …

Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed
in tissues including renal epithelia, associate with abnormal renal development. While …

Heterozygous mutations in the human HNF1B gene are associated with maturity-onset
diabetes of the young type 5 (MODY5) and pancreas hypoplasia. In mouse, Hnf1b …

Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the
development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract …

Cilia are organelles that project from most eukaryotic organisms and cell types. Their
pervasiveness stems from having remarkably versatile propulsive and sensory functions …

Kinesins are microtubule-based motor proteins that are well known for their key roles in cell
biological processes ranging from cell division, to intracellular transport of mRNAs, proteins …

Hepatocyte nuclear factor-1β (HNF-1β) is a transcription factor required for the expression of
several renal cystic genes and whose prenatal deletion leads to polycystic kidney disease …