Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

As the major cellular component of the innate immune system in the central nervous system
(CNS) and the first line of defense whenever injury or disease occurs, microglia play a …

The carbamate group is a key structural motif in many approved drugs and prodrugs. There
is an increasing use of carbamates in medicinal chemistry and many derivatives are …

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …

Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …

Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids
that have been implicated in many physiologic disorders, including obesity, metabolic …

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality.
Consequences vary from mild cognitive impairment to death and, no matter the severity of …

Microglia, the resident immune cells of the central nervous system, mediate brain
homeostasis by controlling neuronal proliferation/differentiation and synaptic activity. In …

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …