Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Cardiac muscle contraction is distinct from the contraction of other muscle types. The heart
continuously undergoes contraction–relaxation cycles throughout an animal's lifespan. It …

Muscle contraction is produced via the interaction of myofilaments and is regulated so that
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …

In this study, we investigated the role of the super-relaxed (SRX) state of myosin in the
structure–function relationship of sarcomeres in the hearts of mouse models of …

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …

Novel cardiac troponin activators were identified using a high throughput cardiac myofibril
ATPase assay and confirmed using a series of biochemical and biophysical assays. HTS hit …

In this report, we establish a straightforward method for estimating the equilibrium constant
for the creatine kinase reaction (CK Keq ″) over wide but physiologically and …

Myocyte disarray is a hallmark of many cardiac disorders. However, the relationship
between alterations in the orientation of individual myofibrils and myofilaments to disease …

The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated
muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of …

Aberrant regulation of myocardial force production represents an early biomechanical defect
associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly …