Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on
humans. We revisit important concepts from the older literature and describe the interaction …

Neurovascular coupling reflects the close temporal and regional linkage between neural
activity and cerebral blood flow. Although providing mechanistic insight, our understanding …

Mental processes and their neural substrates are intimately linked to the homeostatic control
of internal bodily state. There are a set of distinct interoceptive pathways that directly and …

Senescence is a leading cause of mortality, disability, and non‐communicable chronic
diseases in older adults. Mounting evidence indicates that the presence of cardiovascular …

There is considerable utility in the use of transcranial Doppler ultrasound (TCD) to assess
cerebrovascular function. The brain is unique in its high energy and oxygen demand but …

The response of cerebral vasculature to exercise is different from other peripheral
vasculature; it has a small vascular bed and is strongly regulated by cerebral autoregulation …

Cerebral blood flow (CBF) and its distribution are highly sensitive to changes in the partial
pressure of arterial CO2 (PaCO2). This physiological response, termed cerebrovascular …

Heat stress increases human morbidity and mortality compared to normothermic conditions.
Many occupations, disease states, as well as stages of life are especially vulnerable to the …

Sport-related concussion (SRC) is a major health problem, affecting millions of athletes each
year. While the clinical effects of SRC (eg, symptoms and functional impairments) typically …