Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Importance Controlled clinical laboratory studies have shown that cannabidiol (CBD) can
sometimes attenuate or exacerbate the effects ofΔ9-tetrahydrocannabinol (Δ9-THC). No …

Caffeine, theophylline, theobromine, and paraxanthine administered to animals and humans
distribute in all body fluids and cross all biological membranes. They do not accumulate in …

Understanding cannabis‐drug interactions is critical given regulatory changes that have
increased access to and use of cannabis. Cannabidiol (CBD) and Δ‐9 …

The suitability of the capillary dried blood spot (DBS) sampling method was assessed for
simultaneous phenotyping of cytochrome P450 (CYP) enzymes and P‐glycoprotein (P‐gp) …

Because of the high research and development cost of new drugs, the long development
process of new drugs, and the high failure rate at later stages, combining past drugs has …

Ginseng is the most frequently used herbal medicine for immune system stimulation and as
an adjuvant with prescribed drugs owing to its numerous pharmacologic activities. It is …

Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary
human hepatocytes are the gold standard model for the assessment of drug efficacy, safety …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Numerous cocktails using concurrent
administration of several cytochrome P450 (CYP) isoform‐selective probe drugs have been …