Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …
Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
J Storm, JS Jespersen, KB Seydel… - EMBO Molecular …, 2019 - embopress.org
Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …
microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow …
Linking EPCR-binding PfEMP1 to brain swelling in pediatric cerebral malaria
A Kessler, S Dankwa, M Bernabeu, V Harawa… - Cell host & …, 2017 - cell.com
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined …
the mechanisms leading to swelling remain poorly defined. Here, we combined …
Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment
The malaria parasite life cycle includes asexual replication in human blood, with a
proportion of parasites differentiating to gametocytes required for transmission to …
proportion of parasites differentiating to gametocytes required for transmission to …
EPCR and malaria severity: the center of a perfect storm
M Bernabeu, JD Smith - Trends in parasitology, 2017 - cell.com
Severe malaria due to Plasmodium falciparum infection causes nearly half a million deaths
per year. The different symptomatology and disease manifestations among patients have …
per year. The different symptomatology and disease manifestations among patients have …
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains
Most severe Plasmodium falciparum infections are experienced by young children. Severe
symptoms are precipitated by vascular sequestration of parasites expressing a particular …
symptoms are precipitated by vascular sequestration of parasites expressing a particular …
The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum …
By attaching infected erythrocytes to the vascular lining, Plasmodium falciparum parasites
leave blood circulation and avoid splenic clearance. This sequestration is central to …
leave blood circulation and avoid splenic clearance. This sequestration is central to …
Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria
Background Expression of group A and the A-like subset of group B Plasmodium falciparum
erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The …
erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The …
The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria
The impact of cerebral malaria on the transcriptional profiles of cerebral tissues is difficult to
study using noninvasive approaches. We isolated plasma extracellular vesicles (EVs) from …
study using noninvasive approaches. We isolated plasma extracellular vesicles (EVs) from …