The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Osteopetrosis is a genetic condition of increased bone mass, which is caused by defects in
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …

ABSTRACT The vacuolar H+-ATPase (V-ATPase) has long been appreciated to function as
an electrogenic H+ pump. By altering the pH of intracellular compartments, the V-ATPase …

The dysregulation of ROS production and osteoclastogenesis is involved in the progress of
osteoporosis. To identify novel and effective targets to treat this disease, it is important to …

Biased left-right asymmetry is a fascinating and medically important phenomenon. We
provide molecular genetic and physiological characterization of a novel, conserved, early …

The vacuolar-type H+-ATPase (V-ATPase) proton pump is a macromolecular complex
composed of at least 14 subunits organized into two functional domains, V1 and V0. The …

Osteoclasts resorb bone by attaching to the surface and then secreting protons into an
extracellular compartment formed between osteoclast and bone surface. This secretion is …

Vacuolar H+-ATPase (V-ATPase) is a multi-subunit enzyme with a membrane peripheral
catalytic (V 1) and an intrinsic (V o) sector. We have identified three cDNA clones coding for …

Vacuolar H+-ATPases (V-ATPases) are essential for acidification of intracellular
compartments and for proton secretion from the plasma membrane in kidney epithelial cells …

Marine macrolides latrunculins are highly specific toxins which effectively depolymerize
actin filaments (generally F-actin) in all eukaryotic cells. We show that latrunculin B is …