Determinants, maintenance, and function of organellar pH
SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …
Osteopetrosis: genetics, treatment and new insights into osteoclast function
C Sobacchi, A Schulz, FP Coxon, A Villa… - Nature Reviews …, 2013 - nature.com
Osteopetrosis is a genetic condition of increased bone mass, which is caused by defects in
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …
osteoclast formation and function. Both autosomal recessive and autosomal dominant forms …
The vacuolar-type H+-ATPase at a glance – more than a proton pump
ME Maxson, S Grinstein - Journal of cell science, 2014 - journals.biologists.com
ABSTRACT The vacuolar H+-ATPase (V-ATPase) has long been appreciated to function as
an electrogenic H+ pump. By altering the pH of intracellular compartments, the V-ATPase …
an electrogenic H+ pump. By altering the pH of intracellular compartments, the V-ATPase …
[HTML][HTML] The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling
X Sun, Z Xie, B Hu, B Zhang, Y Ma, X Pan, H Huang… - Redox biology, 2020 - Elsevier
The dysregulation of ROS production and osteoclastogenesis is involved in the progress of
osteoporosis. To identify novel and effective targets to treat this disease, it is important to …
osteoporosis. To identify novel and effective targets to treat this disease, it is important to …
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
DS Adams, KR Robinson, T Fukumoto, S Yuan… - 2006 - journals.biologists.com
Biased left-right asymmetry is a fascinating and medically important phenomenon. We
provide molecular genetic and physiological characterization of a novel, conserved, early …
provide molecular genetic and physiological characterization of a novel, conserved, early …
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption
The vacuolar-type H+-ATPase (V-ATPase) proton pump is a macromolecular complex
composed of at least 14 subunits organized into two functional domains, V1 and V0. The …
composed of at least 14 subunits organized into two functional domains, V1 and V0. The …
Osteoclastic acidification pathways during bone resorption
AV Rousselle, D Heymann - Bone, 2002 - Elsevier
Osteoclasts resorb bone by attaching to the surface and then secreting protons into an
extracellular compartment formed between osteoclast and bone surface. This secretion is …
extracellular compartment formed between osteoclast and bone surface. This secretion is …
Three subunit a isoforms of mouse vacuolar H+-ATPase: preferential expression of the a3 isoform during osteoclast differentiation
T Toyomura, T Oka, C Yamaguchi, Y Wada… - Journal of biological …, 2000 - ASBMB
Vacuolar H+-ATPase (V-ATPase) is a multi-subunit enzyme with a membrane peripheral
catalytic (V 1) and an intrinsic (V o) sector. We have identified three cDNA clones coding for …
catalytic (V 1) and an intrinsic (V o) sector. We have identified three cDNA clones coding for …
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump
M Lu, LS Holliday, L Zhang, WA Dunn… - Journal of Biological …, 2001 - ASBMB
Vacuolar H+-ATPases (V-ATPases) are essential for acidification of intracellular
compartments and for proton secretion from the plasma membrane in kidney epithelial cells …
compartments and for proton secretion from the plasma membrane in kidney epithelial cells …
Latrunculin B-induced plant dwarfism: plant cell elongation is F-actin-dependent
Marine macrolides latrunculins are highly specific toxins which effectively depolymerize
actin filaments (generally F-actin) in all eukaryotic cells. We show that latrunculin B is …
actin filaments (generally F-actin) in all eukaryotic cells. We show that latrunculin B is …