Obesity is widely recognized as a major global health problem caused by a chronic energy
imbalance resulting from a combination of excess caloric intake and insufficient energy …

Microglia play key roles in the post‐ischemic inflammatory response and damaged tissue
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …

Aims The crosstalk between ferroptosis and neuroinflammation considerably impacts the
pathogenesis of cerebral ischemia–reperfusion injury (CIRI). Neutral polysaccharide from …

Background Immune infiltration plays an important role in the course of ischemic stroke (IS)
progression. Cuproptosis is a newly discovered form of programmed cell death. To date, no …

NLRP3 inflammasome has been implicated in neutrophil polarization and extrusion of
neutrophil extracellular traps (NETs) in vitro and facilitates secretion of Il1-beta (IL-1β) …

Background: Ischemic stroke (IS) is one of the most severe brain diseases. Animal models
with anesthesia are actively used to study stroke genomics and pathogenesis. However, the …

Vitamin D supplementation is reported to have anti-inflammatory and neuroprotective effects
during cerebral ischemia-reperfusion injury (CIRI), but the protective mechanism has not …

Ischemic stroke presents a global health challenge, necessitating an in-depth
comprehension of its pathophysiology and therapeutic strategies. While reperfusion therapy …

Ferroptosis is a newly discovered type of regulated cell death participated in multiple
diseases. Different from other classical cell death programs such as necrosis and apoptosis …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection, and its morbidity and mortality rates are increasing annually. It is an independent …