Glioblastoma (GBM) is the most common type of primary brain tumor in adults. Despite
recent advances in cancer therapy, including the breakthrough of immunotherapy, the …

Besides its well-described impact in immunosuppressed patients, the role of human
cytomegalovirus (HCMV) in the pathogenesis of cancer has been more recently …

Simple Summary Whether the human cytomegalovirus (HCMV) is present in samples
obtained from patients with glioblastoma (GBM) has been a matter under debate during the …

Recent studies have demonstrated abundant transcription of a set of noncoding RNAs
(ncRNAs) preferentially within tumors as opposed to normal tissue. Using an approach from …

Gliomas are the most common malignant brain tumors and account for around 60% of all
primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV …

Next generation sequencing (NGS) can globally interrogate the genetic composition of
biological samples in an unbiased yet sensitive manner. The objective of this study was to …

Oncolytic virotherapy holds promise of effective immunotherapy against otherwise
nonresponsive cancers such as glioblastoma. Our previous findings have shown that …

Background Experimental findings have suggested that human cytomegalovirus (HCMV)
infection of tumor cells may exert oncomodulatory effects that enhance tumor malignancy …

Cytomegalovirus (CMV) belongs to the Herpesviridae family and is also known as human
herpesvirus type 5. It is a common virus that usually doesn't cause any symptoms in healthy …

Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that
often create a chronic inflammatory and immunosuppressive microenvironment that restricts …