According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

▪ Abstract A decade after the discovery of electrospray and matrix-assisted laser desorption
ionization (MALDI), methods that finally allowed gentle ionization of large biomolecules …

Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

Ion sources for molecular mass spectrometry are usually driven by direct current power
supplies with no user control over the total charges generated. Here, we show that the …

Mass spectrometry-based proteomics has greatly benefitted from enormous advances in
high resolution instrumentation in recent years. In particular, the combination of a linear ion …

When non-mass spectrometrists are talking about mass spectrometry it rather often sounds
as if they were telling a story out of Poe's Tales of Mystery and Imagi-tion. Indeed, mass …

Peptide sequencing is the basis of mass spectrometry–driven proteomics. Here we show
that in the linear ion trap–orbitrap mass spectrometer (LTQ Orbitrap) peptide ions can be …

The most commonly used activation method in the tandem mass spectrometry (MS) of
peptides and proteins is energetic collisions with a neutral target gas. The overall process of …

Multiply charged anions derived from electrospray ionization of the sodium salts of various
small oligonucleotides (n= 4− 8) have been subjected to tandem mass spectrometry …

Collisional activation has played an essential role in the development of mass
spectrometry/mass spectrometry (MS/MS). It was the first activation method to be employed …