Epithelial-mesenchymal transition (EMT) as a trans-differentiation program and a key
process in tumor progression is linked positively with increased expansion of cancer stem …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

During cancer metastasis, tumor cells likely navigate, in a collective manner, discrete tissue
spaces comprising inherently heterogeneous extracellular matrix microstructures where …

Proteins are crucial in regulating every aspect of RNA life, yet understanding their
interactions with coding and noncoding RNAs remains limited. Experimental studies are …

Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer,
accounting for over 90% of cases. As pyruvate metabolic pathways are often dysregulated in …

Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers and is driven by a
multitude of viral, metabolic, and lifestyle factors initiating liver injury that subsequently …

Fast and precise measurements of live single-cell biophysical properties is significant in
disease diagnosis, cytopathologic analysis, etc. Existing methods still suffer from unsatisfied …

Precise sampling of undissolved chemical components from subcellular regions of living
single cells is a prerequisite for their in-depth analysis, which could promote understanding …

Background Alpha-1 antitrypsin deficiency (AATD) is an inherited disease, the common
variant caused by a Pi* Z mutation in the SERPINA1 gene. Pi* Z AAT increases the risk of …

The liver is the largest glandular organ in the body and has a unique distribution of cells and
biomolecules. However, the treatment outcome of end-stage liver disease is extremely poor …