Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

Impulse control and/or gambling disorders can be triggered by dopamine agonist therapies
used to treat Parkinson9s disease, but the cognitive and neurobiological mechanisms …

Acute stress has various effects on cognition, executive function and certain forms of
cost/benefit decision making. Recent studies in rodents indicate that acute stress …

Rationale Win-paired stimuli can promote risk taking in experimental gambling paradigms in
both rats and humans. We previously demonstrated that atomoxetine, a noradrenaline …

Rationale The use of illicit opioids has arguably never been more risky; street drug potency
can be dangerously high, is often unknown to the consumer, and results in multiple daily …

Adaptive behavior depends on appropriate responses to environmental uncertainty.
Incidental sensory events might simply be distracting and increase errors, but alternatively …

Computational psychiatry focuses on identifying core cognitive processes that appear
altered across distinct psychiatric disorders. Temporal discounting of future rewards and …

Rationale For many mammals, engaging in social play behavior as a juvenile is important
for cognitive, social, and emotional health as an adult. A playful phenotype reflects a …

Sign-and goal-tracking are behaviors seen in many species when a conditioned stimulus
and it's corresponding unconditioned stimulus are presented at separate locations, and …

Previous research has indicated that reward-paired cues can enhance disadvantageous
risky choice in both humans and rodents. Systemic administration of a serotonin 2C receptor …