The formalin test: an evaluation of the method

A Tjølsen, OG Berge, S Hunskaar, JH Rosland, K Hole - Pain, 1992 - journals.lww.com
The formalin test for nociception, which is predominantly used with rats and mice, involves
moderate, continuous pain generated by injured tissue. In this way it differs from most …

Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors

D Van Rossum, UK Hanisch, R QUIRION - Neuroscience & Biobehavioral …, 1997 - Elsevier
VAN ROSSUM, DU-K. HANISCH AND R. QUIRION. Neuroanatomical localization,
pharmacological characterization and functions of CGRP, related peptides and their …

Migraine attacks are of peripheral origin: the debate goes on

TP Do, A Hougaard, G Dussor, KC Brennan… - The Journal of …, 2023 - Springer
Background Despite the pervasiveness of migraine, the underlying pathophysiological
mechanisms initiating migraine attacks are far from well understood and are matter of …

Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model

CA Porro, M Cavazzuti - Progress in neurobiology, 1993 - Elsevier
Noxious stimuli are thought to modify the activity of several populations of central nervous
system (CNS) cells, which underlie the sensory-discriminative and motivational-affective …

Topography of thalamic and parabrachial calcitonin gene‐related peptide (CGRP) immunoreactive neurons projecting to subnuclei of the amygdala and extended …

W D'Hanis, R Linke… - Journal of Comparative …, 2007 - Wiley Online Library
Injections of calcitonin gene‐related peptide (CGRP) into the amygdala evoke fear‐related
behaviors and antinociceptive effects. In the present study we therefore characterized CGRP …

Calcitonin and its antinociceptive activity: animal and human investigations 1975–1992

PC Braga - Agents and Actions, 1994 - Springer
Calcitonin (CT) is a polypeptide hormone produced in the thyroid gland that regulates, blood
calcium levels and bone calcium metabolism. The unexpected finding of binding sites for …

Antinociceptive effect of calcitonin gene-related peptide in the central nucleus of amygdala: activating opioid receptors through amygdala–periaqueductal gray …

W Xu, T Lundeberg, YT Wang, Y Li, LC Yu - Neuroscience, 2003 - Elsevier
The central nucleus of amygdala (CeA) plays an important role in pain regulation. Calcitonin
gene-related peptide (CGRP)-like immunoreactive fibers and CGRP receptors are …

The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain

R Rizzi, A Bartolomucci, A Moles, F D'Amato… - Neuroscience …, 2008 - Elsevier
Vgf, is a neuro-endocrine specific gene encoding for a large protein precursor of different
peptides. A role for VGF in pain modulation has been suggested from immunohistochemical …

Anti-nociceptive effects of calcitonin gene-related peptide in nucleus raphe magnus of rats: an effect attenuated by naloxone

YH Huang, G Brodda-Jansen, T Lundeberg, LC Yu - Brain research, 2000 - Elsevier
The present study investigated the role of calcitonin gene-related peptide (CGRP) on
nociception in nucleus raphe magnus (NRM) and the interaction between CGRP and opioid …

Involvement of calcitonin gene-related peptide and its receptor in anti-nociception in the periaqueductal grey of rats

LC Yu, XH Weng, JW Wang, T Lundeberg - Neuroscience letters, 2003 - Elsevier
The present study investigated the role of calcitonin gene-related peptide (CGRP) in the
modulation of nociception in periaqueductal grey (PAG) of rats. Hindpaw withdrawal …