Targeting FGFR signaling in cancer
The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …
conserved signaling cascade that regulates several basic biologic processes, including …
FGFR inhibitors in oncology: insight on the management of toxicities in clinical practice
Simple Summary FGFR inhibitors evolved as therapeutic options in cholangiocarcinoma
and urothelial malignancies. Given the implications of FGFR pathway in various …
and urothelial malignancies. Given the implications of FGFR pathway in various …
[HTML][HTML] Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application
YK Chae, K Ranganath, PS Hammerman, C Vaklavas… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase
signaling pathway that has a fundamental role in many biologic processes including …
signaling pathway that has a fundamental role in many biologic processes including …
Facts and new hopes on selective FGFR inhibitors in solid tumors
Precision oncology relies on the identification of molecular alterations, responsible for tumor
initiation and growth, which are suitable targets of specific inhibitors. The development of …
initiation and growth, which are suitable targets of specific inhibitors. The development of …
[HTML][HTML] A randomized, open-label study of the efficacy and safety of AZD4547 monotherapy versus paclitaxel for the treatment of advanced gastric adenocarcinoma …
E Van Cutsem, YJ Bang, W Mansoor, RD Petty… - Annals of …, 2017 - Elsevier
ABSTRACT Background Approximately 5%–10% of gastric cancers have a fibroblast growth
factor receptor-2 (FGFR2) gene amplification. AZD4547 is a selective FGFR-1, 2, 3 tyrosine …
factor receptor-2 (FGFR2) gene amplification. AZD4547 is a selective FGFR-1, 2, 3 tyrosine …
Prevention and treatment of FGFR inhibitor-associated toxicities
Fibroblast growth factor receptor (FGFR) inhibitors have shown promising results in terms of
objective response rates in phase I/II trials in various malignancies that harbor FGFR genetic …
objective response rates in phase I/II trials in various malignancies that harbor FGFR genetic …
Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study
H Saka, C Kitagawa, Y Kogure, Y Takahashi… - Investigational new …, 2017 - Springer
Background AZD4547 is a potent, oral, highly selective fibroblast growth factor receptor
(FGFR) inhibitor in clinical development for treating tumours with a range of FGFR …
(FGFR) inhibitor in clinical development for treating tumours with a range of FGFR …
Complexity of FGFR signalling in metastatic urothelial cancer
A Rodriguez-Vida, M Saggese, S Hughes… - Journal of Hematology & …, 2015 - Springer
Background Urothelial cancers (UC) are the fourth most common tumours worldwide after
prostate (or breast), lung and colorectal cancer. Despite recent improvements in their …
prostate (or breast), lung and colorectal cancer. Despite recent improvements in their …
[HTML][HTML] Targeting the fibroblast growth factor receptor 2 in gastric cancer: promise or pitfall?
Gastric cancer is the third leading cause of death from cancer worldwide. Systemic
chemotherapy remains the mainstay therapeutic option for this poor prognosis cancer …
chemotherapy remains the mainstay therapeutic option for this poor prognosis cancer …
ASP5878, a novel inhibitor of FGFR1, 2, 3, and 4, inhibits the growth of FGF19-expressing hepatocellular carcinoma
T Futami, H Okada, R Kihara, T Kawase… - Molecular Cancer …, 2017 - AACR
Hepatocellular carcinoma is an aggressive cancer with poor prognosis. Fibroblast growth
factor 19, a member of the fibroblast growth factor family, is a ligand for fibroblast growth …
factor 19, a member of the fibroblast growth factor family, is a ligand for fibroblast growth …