T-wave alternans and the susceptibility to ventricular arrhythmias

SM Narayan - Journal of the American College of Cardiology, 2006 - jacc.org
T-wave alternans (TWA) reflects beat-to-beat fluctuations in the electrocardiographic T-
wave, and is associated with dispersion of repolarization and the mechanisms for sudden …

Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: a meta-analysis

AK Gehi, RH Stein, LD Metz, JA Gomes - Journal of the American College …, 2005 - jacc.org
Objectives: The objective of this study was to perform a meta-analysis of the predictive value
of microvolt T-wave alternans (MTWA) testing for arrhythmic events in a wide variety of …

Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death

ML Walker, DS Rosenbaum - Cardiovascular research, 2003 - academic.oup.com
For nearly 100 years, beat to beat alternation of T wave amplitude, termed T wave alternans
(TWA), has been closely linked to electrical instability in the heart. TWA is now established …

Nonsustained ventricular tachycardia

DG Katritsis, W Zareba, AJ Camm - Journal of the American College of …, 2012 - jacc.org
Nonsustained ventricular tachycardia (NSVT) has been recorded in a wide range of
conditions, from apparently healthy individuals to patients with significant heart disease. In …

Pathophysiological basis and clinical application of T-wave alternans

AA Armoundas, GF Tomaselli, HD Esperer - Journal of the American …, 2002 - jacc.org
We review the contemporary understanding of the pathophysiology of repolarization
alternans and present a perspective on the use of T-wave alternans (TWA) as a risk …

Prognostic significance of risk stratifiers of mortality, including T wave alternans, after acute myocardial infarction: Results of a prospective follow‐up study

JM Tapanainen, AM STILL… - Journal of …, 2001 - Wiley Online Library
Noninvasive Risk Assessment Including TWA After AMI. Introduction: Occurrence of
sustained microvolt‐level T wave alternans (TWA) at a specified heart rate has been …

Prognosis determination in heart failure

EJ Eichhorn - The American journal of medicine, 2001 - amjmed.com
Randomized controlled clinical trials as well as large community-based trials have
succeeded in identifying more than 50 biochemical, hemodynamic, functional, demographic …

Onset heart rate of microvolt-level T-wave alternans provides clinical and prognostic value in nonischemic dilated cardiomyopathy

H Kitamura, Y Ohnishi, K Okajima, A Ishida… - Journal of the American …, 2002 - jacc.org
Objectives: This study was designed to determine the prognostic value of onset heart rate
(OHR) in T-wave alternans (TWA) in patients with nonischemic dilated cardiomyopathy …

Human cardiac fibroblast number and activation state modulate electromechanical function of hiPSC‐cardiomyocytes in engineered myocardium

CE Rupert, TY Kim, BR Choi… - Stem cells …, 2020 - Wiley Online Library
Cardiac tissue engineering using hiPSC‐derived cardiomyocytes is a promising avenue for
cardiovascular regeneration, pharmaceutical drug development, cardiotoxicity evaluation …

Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias

MB Thomsen, J Matz, PGA Volders, MA Vos - Pharmacology & therapeutics, 2006 - Elsevier
Torsades de pointes (TdP) is a potentially lethal cardiac arrhythmia that can occur as an
unwanted adverse effect of various pharmacological therapies. Before a drug is approved …