The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of …

RNA helicases are critical regulators at the nexus of multiple pathways of RNA metabolism,
and in the complex cellular environment, tight spatial and temporal regulation of their activity …

DEAD-box helicases catalyze the ATP-dependent unwinding of RNA duplexes. They share
a helicase core formed by two RecA-like domains that carries a set of conserved motifs …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

Recent technological advancements have shown tremendous mechanistic
accomplishments in our understanding of the mechanism of messenger RNA translation in …

During eukaryotic translation initiation, the small ribosomal subunit, assisted by initiation
factors, locates the messenger RNA start codon by scanning from the 5′ cap. This process …

The ribonuclease III enzyme Drosha has a central role in the biogenesis of microRNA
(miRNA) by binding and cleaving hairpin structures in primary RNA transcripts into precursor …

Eukaryotic translation initiation factor 4A (eIF4A) is a DEAD-box protein that participates in
translation initiation. As an ATP-dependent RNA helicase, it is thought to resolve secondary …