The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical
role in pathogenesis of the neurodegenerative disorders known as prion diseases. A …

Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

Although its involvement in prion replication and neurotoxicity during transmissible
spongiform encephalopathies is undisputed, the physiological role of the cellular prion …

Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most
abundantly found in the outer membrane of neurons. Due to structural characteristics (a …

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of
β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In …

After the discovery of prion phenomenon, the physiological role of the cellular prion protein
(PrP C) remained elusive. In the past decades, molecular and cellular analysis has shed …

The cellular prion protein, PrP C, is a small, cell surface glycoprotein with a function that is
currently somewhat ill defined. It is also the key molecule involved in the family of …

Creutzfeldt–Jakob disease (CJD) is a neurodegenerative disorder caused by prion protein
(PrP) misfolding, clinically recognized by cognitive and motor deficits …