Crisis in the gut: Navigating gastrointestinal challenges in Gulf War Illness with bioengineering

CA Collier, A Salikhova, S Sabir, S Foncerrada… - Military Medical …, 2024 - Springer
Abstract Gulf War Illness (GWI) is characterized by a wide range of symptoms that manifests
largely as gastrointestinal symptoms. Among these gastrointestinal symptoms, motility …

A review of pre-clinical models for Gulf War Illness

ACR Ribeiro, LS Deshpande - Pharmacology & therapeutics, 2021 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic multisymptomatic disorder that afflicts over 1/3rd
of the 1991 GW veterans. It spans multiple bodily systems and presents itself as a syndrome …

[HTML][HTML] Oral nano-curcumin in a model of chronic Gulf War illness alleviates brain dysfunction with modulation of oxidative stress, mitochondrial function …

S Attaluri, M Arora, LN Madhu, M Kodali… - Aging and …, 2022 - pmc.ncbi.nlm.nih.gov
Unrelenting cognitive and mood impairments concomitant with incessant oxidative stress
and neuroinflammation are among the significant symptoms of chronic Gulf War Illness …

Subchronic oral cylindrospermopsin exposure alters the host gut microbiome and is associated with progressive hepatic inflammation, stellate cell activation, and mild …

P Saha, M Upright, D Bose, S Roy, A Trivedi, M More… - Toxins, 2022 - mdpi.com
Epidemiological studies have reported a strong association between liver injury and
incidences of hepatocellular carcinoma in sections of humans globally. Several preclinical …

Recent research trends in Neuroinflammatory and neurodegenerative disorders

J Cohen, A Mathew, KD Dourvetakis… - Cells, 2024 - mdpi.com
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD),
Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis …

Specific, Measurable, Action-Oriented, Realistic, and Timed goals and the Personal Health Inventory in a wellness group for veterans with GWI

M McQuade, CP Polizzi, E Katz, M Ting, C Busser… - Medical …, 2024 - journals.lww.com
Background: Interventions based on the Veterans Health Administration's (VHA) Whole
Health (WH) initiative may be beneficial for veterans with Gulf War Illness (GWI) through …

Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans

M Kodali, T Jankay, AK Shetty, DS Reddy - Psychopharmacology, 2023 - Springer
This article describes the pathophysiology and potential treatments for Gulf War Illness
(GWI), which is a chronic neuropsychiatric illness linked to a combination of chemical …

Andrographolide attenuates gut-brain-axis associated pathology in gulf war illness by modulating bacteriome-virome associated inflammation and microglia-neuron …

P Saha, PT Skidmore, LRA Holland, A Mondal, D Bose… - Brain sciences, 2021 - mdpi.com
Gulf War Illness (GWI) is a chronic multi-symptomatic illness that is associated with fatigue,
pain, cognitive deficits, and gastrointestinal disturbances and presents a significant …

Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models

P Saha, D Bose, V Stebliankin, T Cickovski, RK Seth… - Scientific reports, 2022 - nature.com
A strong association between exposure to the common harmful algal bloom toxin
microcystin and the altered host gut microbiome has been shown. We tested the hypothesis …

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness

E Slevin, S Koyama, K Harrison, Y Wan… - Journal of Cellular …, 2023 - Wiley Online Library
Abstract Gulf War Illness (GWI) has been reported in 25%–35% of veterans returned from
the Gulf war. Symptoms of GWI are varied and include both neurological and gastrointestinal …