Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …

Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics,
mainly microtubule-targeting agents (MTAs), such as taxanes and vinca alkaloids, are …

High levels of cancer aneuploidy are frequently associated with poor prognosis. To examine
the relationship between aneuploidy and cancer progression, we analyzed a series of …

Lung squamous cell carcinoma (LUSC) is often diagnosed at the advanced stage with poor
prognosis. The mechanisms of its pathogenesis and prognosis require urgent elucidation …

Increased rates of locoregional recurrence are observed in patients with basal-like breast
cancer (BC) despite the use of radiation therapy (RT); therefore, approaches that result in …

The homogeneity and heterogeneity in somatic mutations, copy number alterations and
methylation across different cancer types have been extensively explored. However, the …

The present review aims to explore the potential targets/partners for future targeted
radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively …

Abnormal expression of TTK kinase has been associated with the initiation, progression,
and therapeutic resistance of breast and other cancers, but its roles remain to be clarified. In …

Loss of mitosis regulation is a common feature of malignant cells that leads to aberrant cell
division with inaccurate chromosome segregation. The mitotic checkpoint is responsible for …

Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase
governing spindle assembly checkpoint activation and sister chromatid separation in …