Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …

Bile acids (BAs) are not only digestive surfactants but also important cell signaling
molecules, which stimulate several signaling pathways to regulate some important …

Ligand-activated nuclear receptors, including peroxisome proliferator-activated receptor
alpha (PPARα), pregnane X receptor, and constitutive androstane receptor, were first …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the
world, and it comprises a spectrum of hepatic abnormalities from simple hepatic steatosis to …

Nonalcoholic fatty liver disease (NAFLD) is primarily caused by abnormal lipid metabolism
and the accumulation of triglycerides in the liver. NAFLD is also associated with hepatic …

Bile salts play crucial roles in allowing the gastrointestinal system to digest, transport and
metabolize nutrients. They function as nutrient signaling hormones by activating specific …

Background The human intestinal microbiota is a key regulator of host metabolic and
immune functions and alterations in the microbiome ('dysbiosis') have been implicated in …

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its
underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor …

Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such
as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have …